The Bioanalytics and Analytical Sensors course will introduce the main aspects of miniaturization of analytical systems, mainly for bioanalytical purposes. In the first part, incentive for miniaturization will be presented, followed by technical introductions on how to produce microfluidic systems, how to deal with various surface chemistries to define hydrophilic/hydrophobic zones or pattern biomolecules on surfaces, and how to drive fluids in microfluidic formats.
After this technical first part, sessions will be given on the integration of classical analytical systems in microfluidic formats (capillary electrophoresis, HPLC, immunoassays, affinity assays...), highlighting for each application the core features of miniaturization against classical format (speed, role of diffusion,...). At the end of this applicative part, emphasis will be put on analytical schemes that are unique to miniaturized format and cannot be carried out in classical format.
The third part of the course will review real-life applications of analytical microsystems.
- Professor: Niels Lion