The comfort and well-being of occupants of buildings have become the central values of the modern built environment. Therefore, engineering of the human-centered indoor environment and understanding of the key parameters influencing it is a crucial skill to learn in order to be able to face the current challenges of the society and building industry. This course will provide an integrated approach to analyze indoor thermal comfort by examining the correlation between indoor thermal environment, building envelope performance, and thermal conditioning systems (HVAC). Particularly, thermodynamics of heat flows that an occupant is exposed to along with thermodynamic processes happening across the building envelope and within the mechanical HVAC system will be analyzed during the course. In addition to space conditioning, hot water demand and supply in buildings will be analyzed.